abstract：:Exposure to acute, inescapable stress produces a facilitation of subsequent classical eyeblink conditioning in male rats. The same stress exposure produces a profound deficit in classical eyeblink conditioning in females. Activation of N-methyl-d-aspartate receptors (NMDAr) is necessary for the effect of stress on lea...

journal_title：Neurobiology of learning and memory

authors： Waddell J,Mallimo E,Shors T

更新日期：2010-01-01 00:00:00

abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

journal_title：Neurobiology of learning and memory

authors： McKinney BC,Sze W,Lee B,Murphy GG

更新日期：2009-11-01 00:00:00

abstract：:Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in th...

journal_title：Neurobiology of learning and memory

authors： Kinney JW,Sanchez-Alavez M,Barr AM,Criado JR,Crawley JN,Behrens MM,Henriksen SJ,Bartfai T

更新日期：2009-10-01 00:00:00

abstract：:When placed in a novel environment, mice tend to explore for a period of time, and then reduce the level of exploration. This reduction in locomotor or exploratory behavior is known as habituation and can occur within a single session or across sessions, respectively, termed intrasession and intersession habituation. ...

journal_title：Neurobiology of learning and memory

authors： Bolivar VJ

更新日期：2009-09-01 00:00:00

abstract：:The use of visual habituation in the study of infant cognition and learning is reviewed. This article traces the history of the technique, underlying theory, and procedural variation in its measurement. In addition, we review empirical findings with respect to the cognitive processes that presumably contribute to habi...

journal_title：Neurobiology of learning and memory

authors： Colombo J,Mitchell DW

更新日期：2009-09-01 00:00:00

abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Wong KL,Chavez CM,Leon MI,Robin KM,Weinberger NM

更新日期：2009-07-01 00:00:00

abstract：:The present study investigated whether the selective nociceptin opioid peptide (NOP) receptor agonist, Ro64-6198, impairs acquisition of fear conditioning through glutamatergic mechanisms. Systemic administration of Ro64-6198 (0.3 and 1mg/kg) or the non-competitive NMDA receptor antagonist, MK-801 (0.03 and 0.1mg/kg) ...

journal_title：Neurobiology of learning and memory

authors： Goeldner C,Reiss D,Wichmann J,Kieffer BL,Ouagazzal AM

更新日期：2009-05-01 00:00:00

abstract：:This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual ...

journal_title：Neurobiology of learning and memory

authors： Abrari K,Rashidy-Pour A,Semnanian S,Fathollahi Y,Jadid M

更新日期：2009-03-01 00:00:00

abstract：:The posterior parietal cortex (PPC) of rats has most recently been defined based on patterns of thalamic and cortical connectivity. The anatomical characteristics of this area suggest that it may be homologous to the PPC of primates and contribute to similar functions. This review summarizes evidence for and against a...

journal_title：Neurobiology of learning and memory

authors： Bucci DJ

更新日期：2009-02-01 00:00:00

abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...

journal_title：Neurobiology of learning and memory

authors： Boccia MM,Blake MG,Baratti CM,McGaugh JL

更新日期：2009-01-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...

journal_title：Neurobiology of learning and memory

authors： Alvarenga TA,Patti CL,Andersen ML,Silva RH,Calzavara MB,Lopez GB,Frussa-Filho R,Tufik S

更新日期：2008-11-01 00:00:00

abstract：:Recent research has begun to demonstrate that specific subunits of GABA(A) receptors may be involved in the normal expression of specific behaviors. The present research used mice with GABA(A) receptors whose alpha1 subunits contained mutations of serine 270 to histidine and leucine 277 to alanine in the TM2 region. T...

journal_title：Neurobiology of learning and memory

authors： Berry RB,Werner DF,Wang X,Jablonski MM,Homanics GE,Mittleman G,Matthews DB

更新日期：2008-10-01 00:00:00

abstract：:Medial thalamic damage is a common cause of severe memory disruption in humans. Both the anterior thalamic nuclei (ATN) and the intralaminar thalamic nuclei (ILN) have been suggested as primary sites of diencephalic injury underlying learning and memory deficits, but their respective roles have yet to be resolved. The...

journal_title：Neurobiology of learning and memory

authors： Wolff M,Gibb SJ,Cassel JC,Dalrymple-Alford JC

更新日期：2008-07-01 00:00:00

abstract：:Research on how steroid hormones mediate mnemonic processes have focused on effects of 17beta-estradiol (E(2)); yet, progesterone (P(4)) co-varies with E(2) across endogenous hormonal milieu, and itself may influence cognitive processes. We investigated the hypothesis that acute P(4) treatment enhances cognitive perfo...

journal_title：Neurobiology of learning and memory

authors： Frye CA,Walf AA

更新日期：2008-07-01 00:00:00

abstract：:An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose pok...

journal_title：Neurobiology of learning and memory

authors： Larson J,Kim D,Patel RC,Floreani C

更新日期：2008-07-01 00:00:00

abstract：:Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counterac...

journal_title：Neurobiology of learning and memory

authors： Zhang M,Cai JX

更新日期：2008-05-01 00:00:00

abstract：:Long-term potentiation (LTP) and depression (LTD) are considered as cellular models for learning and memory. We studied the impact of holeboard training on LTP in the rat CA1 hippocampal region. In 7-week-old Wistar rats a recording electrode was chronically implanted into the hippocampal pyramidal cell layer of the C...

journal_title：Neurobiology of learning and memory

authors： Makhracheva-Stepochkina D,Frey S,Frey JU,Korz V

更新日期：2008-05-01 00:00:00

abstract：:Four experiments were conducted to examine social and emotional memory in the R6/2 transgenic mouse model of Huntington's disease. First, R6/2 mice were tested in a social transmission of food preference task where they had to acquire a preference for a flavoured food (acquisition) and subsequently to learn a preferen...

journal_title：Neurobiology of learning and memory

authors： Ciamei A,Morton AJ

更新日期：2008-05-01 00:00:00

abstract：:It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the fo...

journal_title：Neurobiology of learning and memory

authors： Havekes R,Nijholt IM,Visser AK,Eisel UL,Van der Zee EA

更新日期：2008-05-01 00:00:00

abstract：:There is ongoing debate concerning whether new protein synthesis is necessary for, or even contributes to, memory formation and storage. This review summarizes a contemporary model proposing a role for altered protein synthesis in memory formation and its subsequent stabilization. One defining aspect of the model is t...

journal_title：Neurobiology of learning and memory

authors： Klann E,Sweatt JD

更新日期：2008-03-01 00:00:00

abstract：:Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. ...

journal_title：Neurobiology of learning and memory

authors： Kuo AG,Lee G,McKay BM,Disterhoft JF

更新日期：2008-02-01 00:00:00

abstract：:Spatial working memory and the ability of a cholinesterase inhibitor to enhance memory were assessed at 4, 10, and 16 months of ages in control and Ts65Dn mice, a partial trisomy model of Down syndrome, with possibly significant relationships to Alzheimer's disease as well. In addition, ACh release during memory testi...

journal_title：Neurobiology of learning and memory

authors： Chang Q,Gold PE

更新日期：2008-02-01 00:00:00

abstract：:Although septal infusions of glucose typically have positive effects on memory, we have shown repeatedly that this treatment exacerbates memory deficits produced by co-infusions of gamma-aminobutyric acid (GABA) receptor agonists. The present experiments tested whether this negative interaction between glucose and GAB...

journal_title：Neurobiology of learning and memory

authors： Krebs-Kraft DL,Parent MB

更新日期：2008-02-01 00:00:00

abstract：:The shell division of the nucleus accumbens receives noradrenergic input from neurons in the nucleus of the solitary tract (NTS) that transmit information regarding fluctuations in peripheral hormonal and autonomic activity. Accumbens shell neurons also receive converging inputs from limbic areas such as the hippocamp...

journal_title：Neurobiology of learning and memory

authors： Kerfoot EC,Chattillion EA,Williams CL

更新日期：2008-01-01 00:00:00

abstract：:Although social, physical, and cognitive activities have each been suggested to reduce the risk of Alzheimer's disease (AD), epidemiologic studies cannot determine which activity or combination of activities is most important. To address this question, mutant APP transgenic AD mice were reared long-term in one of four...

journal_title：Neurobiology of learning and memory

authors： Cracchiolo JR,Mori T,Nazian SJ,Tan J,Potter H,Arendash GW

更新日期：2007-10-01 00:00:00

abstract：:New neurons are continually produced in the adult mammalian brain from progenitor cells located in specific brain regions, including the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. We hypothesized that neurogenesis occurs in the canine brain and is reduced with age. We examined neurogenesis in the ...

journal_title：Neurobiology of learning and memory

authors： Siwak-Tapp CT,Head E,Muggenburg BA,Milgram NW,Cotman CW

更新日期：2007-09-01 00:00:00

abstract：:The consolidation of newly formed memories occurs slowly, allowing memories to be altered by experience for some time after their formation. Various treatments, including arousal, can modulate memory consolidation when given soon after learning, but the degree of time-dependency of these treatments in humans has not b...

journal_title：Neurobiology of learning and memory

authors： Nielson KA,Powless M

更新日期：2007-07-01 00:00:00

abstract：:Evidence from lesion, electrophysiological, and neuroimaging studies support the hypothesis that the hippocampus and dorsal striatum process afferent inputs in such a way that each structure regulates expression of different behaviors in learning and memory. The present study sought to determine whether rats explicitl...

journal_title：Neurobiology of learning and memory

authors： Gill KM,Bernstein IL,Mizumori SJ

更新日期：2007-05-01 00:00:00

abstract：:We have previously reported that extinction of escape behavior in the water maze due to the removal of the platform coincided with the development of behavioral "despair" in aged and adult rats, as assessed by immobility. The present study examines further predictions derived from the hypothesis that the withholding o...

journal_title：Neurobiology of learning and memory

authors： Schulz D,Huston JP,Buddenberg T,Topic B

更新日期：2007-03-01 00:00:00

abstract：:The cholinergic system has consistently been implicated in Pavlovian fear conditioning. Considerable work has been done to localize specific nicotinic receptor subtypes in the hippocampus and determine their functional importance; however, the specific function of many of these subtypes has yet to be determined. An al...

journal_title：Neurobiology of learning and memory

authors： Vago DR,Kesner RP

更新日期：2007-03-01 00:00:00

abstract：:Androgens can have performance-enhancing effects in some cognitive tasks, but the mechanism of these effects has not been established. Experiments examined whether androgens' actions to bind to intracellular androgen receptors (ARs) in the hippocampus are necessary to enhance cognitive performance in the inhibitory av...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-02-01 00:00:00

abstract：:Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and/or 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, a...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-01-01 00:00:00

abstract：:The present experiment examined whether posttraining noradrenergic activity within the basolateral complex of the amygdala (BLA) is required for mediating the facilitating effects of acutely administered glucocorticoids on memory for auditory-cue classical fear conditioning. Male Sprague-Dawley rats received five pair...

journal_title：Neurobiology of learning and memory

authors： Roozendaal B,Hui GK,Hui IR,Berlau DJ,McGaugh JL,Weinberger NM

更新日期：2006-11-01 00:00:00

abstract：:In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague-Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age...

journal_title：Neurobiology of learning and memory

authors： Hunt PS,Barnet RC,Shea ME,Baker EM

更新日期：2006-11-01 00:00:00

abstract：:Male songbirds learn to produce song within a limited phase early in life; however they continue to learn to recognize songs in adulthood. Studies looking at Zenk activation after exposure to songs learned early in life for song production and songs learned in adulthood show opposite patterns of activation, suggesting...

journal_title：Neurobiology of learning and memory

authors： McKenzie TL,Hernandez AM,MacDougall-Shackleton SA

更新日期：2006-11-01 00:00:00

abstract：:The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine ar...

journal_title：Neurobiology of learning and memory

authors： Soares JC,Fornari RV,Oliveira MG

更新日期：2006-09-01 00:00:00

abstract：:The activation of cAMP response element-binding protein (CREB) after a learning experience is a common feature in the formation of several associative memories. We recently demonstrated that the increase in the hippocampal phosphorylated CREB (pCREB) levels 1 h after a short exploration of an open field (OF) was assoc...

journal_title：Neurobiology of learning and memory

authors： Moncada D,Viola H

更新日期：2006-07-01 00:00:00

abstract：:Androgens are hypothesized to enhance aspects of mnemonic processing. However, it is unclear whether the memory improvement is associated with changes in earlier aspects of information processing, such as attention. The present experiments examined the effects of gonadectomy or supplementation with testosterone or dih...

journal_title：Neurobiology of learning and memory

authors： Johnson RT,Burk JA

更新日期：2006-05-01 00:00:00

abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...

journal_title：Neurobiology of learning and memory

authors： Shors TJ

更新日期：2006-03-01 00:00:00

abstract：:Although environmental enrichment improves spatial memory and alters synaptic plasticity in aged rodents, it is unclear whether all types of enrichment treatments yield similar benefits. The present study examined the effects in aged male mice of three types of enrichment on spatial memory in Morris water maze and rad...

journal_title：Neurobiology of learning and memory

authors： Bennett JC,McRae PA,Levy LJ,Frick KM

更新日期：2006-03-01 00:00:00